I think it was Dr. McElhone who introduced me to the old saw (didn't know it was old, at the time), "Don't think you're really good just because you've mastered the Easy 80 Percent!". Truer words were never spoken.
Today brings yet another example. Pharma had been dining out on filet and caviar for decades with the Easy 80%. Now, the impossible 20% is all that's left. They, we now know, are frauds. They don't work miracles. They don't conjure all these compounds out of their own pockets. They depend on the Damn Gummint for the smarts.
In the 802-patient study, about 9.3 percent of patients treated with an 18 mg dose of selonsertib, and 12.1 percent of patients treated with a lower dose of the drug achieved an improvement of fibrosis by at least one stage, the company said.
However, 13.2 percent of patients treated with a placebo showed an improvement in fibrosis.
When your drug gets hosed by placebo...!!!